The Laboratory of Regenerative and Muscle Biology in the Department of Health Sciences and Technology at ETH Zurich is searching for a part-time animal transgenic specialist. The primary scientific interest and focus of the lab is to study the regenerative potential of stem cells, with an emphasis on pluripotent and skeletal muscle stem cells, using state-of-the-art transgenic models. The lab is seeking a highly motivated, responsible, and organized transgenic specialist to help oversee the generation of rodent transgenic animal models using CRISPR or pluripotent stem cell injections.
Project backgroundThe Laboratory of Regenerative and Muscle Biology, headed by Prof. Ori Bar-Nur, is a multidisciplinary and collaborative group of scientists focused on translating basic research findings into therapeutically applicable treatments. The lab operates at the intersection of molecular and cellular biology, gene- and cell-based therapies, and tissue engineering. It extensively employs transgenesis in projects involving these research areas to advance our understanding of biological processes and to develop potential new therapies for treating muscle diseases.
Job descriptionPrimary responsibilities include:
- Generation of chimeric rodents from ESCs or iPSCs by blastocyst injection or morula aggregation
- Generation of transgenic mice and rats by pronuclear injection, electroporation, or AAV transduction of DNA and CRISPR-Cas9 constructs
- Embryo and sperm cryopreservation
- In vitro fertilization and intracytoplasmic sperm injection
- Reproduction-related surgical interventions (including harvesting oocytes and embryos, sperm collection, and vasectomy)
Profile - You hold at least a BSc degree in Biology, Biochemistry, Biotechnology, Bioengineering, Biomedical Sciences, or a similar research field
- In addition you have working experience in a transgenic animal unit is required, as well as the ability to perform several of the responsibilities outlined in the job description
- Furthermore, certification in LTK-M1 or an equivelant permit to work with lab rodents is essential.
- You are an excellent communicator, collaborative, organized, and reliable
- Strong communication skills and fluency in English are requiered, as the role will involve daily interactions with international PhD students and postdoctoral research fellows
We offer - Additional training will be provided for the listed tasks
- The RMB Lab is located in the SLA building on the Schwerzenbach Campus of ETH Zurich, a world-leading institute
- We provide a cutting-edge work environment, multiple well-equipped facilities with expert staff, supportive colleagues, and opportunities for innovative and dynamic projects
- We offer a competitive salary and benefits package. The funding and employment terms for this position adhere to the regulations of ETH Zurich
> Working, teaching and research at ETH Zurich
We value diversity and sustainability In line with our values , ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish. Sustainability is a core value for us - we are consistently working towards a climate-neutral future .
