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Master / Intern Biologie / Biochemie 80-100%

Universität Basel • Vollzeit oder Teilzeit • Universität Basel, Region Basel, Switzerland • vor 20Std

The Department of Biomedicine, University of Basel, Switzerland, invites qualified candidates to apply for a position as technical assistant in Biology, Biochemistry and Cancer Research. The candidate will join our multi-disciplinary team and focus on the development and performance of modern assays to evaluate bioactive molecules targeting major signaling pathways in cancer and inflammation.

The working place of the successful candidate is the Department of Biomedicine at Mattenstrasse 28, 4058 Basel.

Projects:
Main focus:

Targeting oncogenicity by covalent inhibitors, a project with a translational aspect. For relevant recent publications see Borsari et al. (2022) J. Am. Chem. Soc. 144(14): 6326–6342; Bissegger et al. (2024) Chem. Sci. 15: 20274-20291 This project is flanked by a basic research project developing novel chemical probes and degraders to dissect mechanisms of adverse effects in cancer and metabolism. For a summary of the latter see: p3.snf database

In parallel we investigate the role of PI3K in allergy, metabolic control, obesity, diabetes and cancer.

Your position

To design, execute and analyze biochemical, biophysical and cellular drug screening assays to evaluate small molecule inhibitors.
Assays include imaging, TR-FRET, inhibitor/target interaction studies, cell culture, automated nanoLt dispensing and more.
Subsequent analysis of results requires GraphPad Prism, KinTek Explorer (kinetic analysis), Excel, and Statistics.
Work in a multi-disciplinary environment collaborating with cell biologists and chemists.
Writing of reports and protocols.

Your profile

The successful candidate holds a master in Biology, Biochemistry, Nanoscience or similar. Qualified interns will be considered.
Expertise with drug screening assays, cell culture and spectroscopic methods is of advantage. An interest for software-based analysis and ev. R-programming is welcome.
The ideal candidate is highly motivated, works independently, pays attention to experimental details, and ingrates rapidly in our team.

We offer you

Application

Please submit your resume (CV) and a letter of motivation, your diplomas, and addresses of 2-3 references to UniBas using the button below.

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