The research group of RNA & Disease at the Institute of Molecular Biology and Biophysics (Department of Biology) at ETH Zurich is looking for a staff scientist and lab manager.
Project backgroundThe lab studies mammalian gene regulation and RNA processing pathways. Projects rely on a combination of state-of-the-art structural, biochemical and cellular assays, including cryo-electron and light microscopy, gene editing, next-generation sequencing, proteomics and reconstitution of large protein-RNA complexes from recombinant proteins. Using these tools the research group aims to determine the molecular basis of disease mechanism in order to find novel targets for treatment.
Job description - Management of daily functions, organization and smooth running of the laboratory. Management and updating of existing databases in the laboratory (e.g. plasmids, antibodies, cell lines).
- Design and improve approaches used in the lab such as cloning, gene editing, protein purification, proteomics.
- Design, execute and interpret experiments to take forward research projects and collaborations.
- Organize and participate in teaching/mentoring of practical courses undertaken in the laboratory for Master's and Undergraduate students of ETH.
The position is available from end of 2025.
Profile - The laboratory is looking for an open minded, flexible, individual with an established record of collaborative research to support and complement ongoing projects in the laboratory.
- The PhD scientist must have around 5 years of hands-on experience post-graduation, with a desire to continue wet lab work. To this end, the candidate must have prior experience with cell culture including handling of human cells, engineering cells using CRISPR/Cas9, recombinant protein expression and purification along with routine transient and stable transfections.
- Familiarity with standard cellular and molecular biology techniques with an excellent understanding of fluorescence microscopy and other spectroscopy techniques is required.
- Previous working knowledge with RNA preparation for next generation sequencing is important.
- Prior research experience in the field of RNA processing and post-transcriptional gene regulation will be given weight.
- The individual must have excellent, presentation skills to report research findings at internal meetings and external scientific conferences along with publications in peer reviewed international scientific journals.
We offerWe offer work in a dynamic and friendly team of international scientists. ETH Zurich is one of the world's leading universities specializing in science and technology. The university is renowned for offering an excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. ETH Zurich promotes independent thinking and creates an environment and community that inspires excellence, with over 30,000 employees and students from more than 120 countries. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.
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